Active forces in confluent cell monolayers
Physical Review Letters American Physical Society 130:3 (2023) 038202
Abstract:
We use a computational phase-field model together with analytical analysis to study how intercellular active forces can mediate individual cell morphology and collective motion in a confluent cell monolayer. We explore the regime where intercellular forces dominate the tissue dynamics, and polar forces are negligible. Contractile intercellular interactions lead to cell elongation, nematic ordering, and active turbulence characterized by motile topological defects. Extensile interactions result in frustration, and perpendicular cell orientations become more prevalent. Furthermore, we show that contractile behavior can change to extensile behavior if anisotropic fluctuations in cell shape are considered.Collective rotational motion of freely-expanding T84 epithelial cell colonies
(2022)
Publisher Correction: Fifty years of ‘More is different’
Nature Reviews Physics Springer Nature 4 (2022)
Abstract:
In the version of the article initially published, the declaration of no competing interests was missing, and has now been inserted in the HTML and PDF versions of the article.Activity gradients in two- and three-dimensional active nematics
Soft Matter Royal Society of Chemistry 18 (2022) 5654-5661