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Sonia Antoranz Contera

Co-director OMS Institute of Nanoscience for Medicine.

BIO

Bio
I am a tenured Associate Professor in Biological Physics at Oxford Physics Department.
My work lies at the interface of physics, biology and nanotechnology. I am an expert in atomic force microscopy of biological systems and I have a special interest in the role of mechanics in biology. We work on mechanics of cells, proteins and membranes and we design nanomaterials that mimic biological functions for bio/medical applications such as drug delivery or cell cultures. Recently I have started a new collaboration with Prof Ian Moore of Oxford Plant Sciences on the nanomechanical aspects of plant cells walls.
I am co-director of the Oxford Martin Programme on Nanotechnology (former Institute of Nanoscience for Medicine) at the Oxford Martin School and Fellow of Green Templeton College. I am a Member of the World Economic Forum Global Agenda Council on Nanotechnology 2014-2016 . Recently I have also become a member of the Strategy Advisory Team of the Engineering and Physical Sciences Research Council (EPSRC) of the UK.

I am a frequent public speaker on the role that Physics and Nanotechnology should (and will!) play in the future of Biology and Medicine and I have published several pieces on Nanotechnology for the general public, such as this one in WIRED magazine on six future forms.

I am a member of several international, multidisciplinary collaboratios, such as the JSPS funded Core-to-Core programme on sensing devicesand the newly established International brain Mechanics and Trauma Lab. I also collaborate with the Scenarios Programme of the Oxford Said Business School.

I graduated in Physics from Universidad Autónoma de Madrid (93), then did graduate studies at Beijing Languages and Culture University (94-95) and worked as a researcher at the Czech Academy of Sciences with Prof. Zlatko Knor, one of the pioneers of atomic scale imaging of surfaces (95, liquid-solid interfaces with STM).
Then I moved to Japan on a Japanese Government Monbushō scholarship and got my PhD from Osaka University's Dept. of Applied Physics, Graduate School of Engineering (2000, Layered materials/scanning probe microscopy, with Prof H Iwasaki as supervisor ).

In 2000 I was awarded an E.U. Fellowship to Japan at the Institute of Scientific and Industrial Research SANKEN, Osaka University (nanostructures in bio/nanoelectronics). Later, I became a Research Assistant Professor in 2002, at the Interdisciplinary Nanoscience Centre, Univ. of Aarhus, Denmark, setting up an AFM lab for biological experiments in Flemming Besenbacher's iNANO centre (HIV-1 RNA tertiary structure, Nanoscience and tissue engineering approaches to improved biocompatibility).
In 2003 I moved to Oxford University Bionanotechnology IRC (carbon nanotube biosensors, bionanointerfaces, and biophysics of membrane proteins, scanning probe microscopy).

In 2007 I became a lecturer and RCUK Academic Fellow at Oxford Physics and in 2008 started the Institute of Nanoscience for Medicine at the Oxford Martin School, which I still codirect.

I work with labs all over the world and I have been a visiting professor at Kwazulu-Natal University Medical Faculty in South Africa, to set AFMs for HIV research, and at Tabata's lab at Tokyo University's Centre for BioNano Integration for appplication of THZ spectroscopy to biological membranes; I have had research stays at Ando's high-speed AFM lab in Kanazawa University and Moscow Lomonosov State University.

Upcoming events

-Speaking at " Spanish Scientific Future " event at the University of Seville on "Nanotechnology in Medicine and applications in regeneration of tissues and organs" 27 Feb 2015

Collaborations

I am member of several networks and research collaborations:
Oxford Martin Programme on Nanotechnology
JSPS funded Core-to-Core programme
International brain Mechanics and Trauma Lab.

I collaborate with researchers all over the world -which if the best part of the job!- right now I am working with:

  • Dr Kislon Voitchovsky (Durham U) on interfaces with AFM
  • Dr Isabel Llorente (UCL) in micro and nanomanipulation of carbon nanoparticles in solution
  • Dr Sonia Trigueros in nanomedicine projects
  • Eneko Axpe (UPV/EHU), nanomechanics or biopolymers and lipids combining AFM and Positron Annihilation Spectroscopy
  • Jihan Zhou, Prof Dehai Liang, Peking University, Nanomechanics of lipid-based nanostructures
  • Ian Moore, Oxford Plant Sciences. "Thinking inside the box: how do plants build organised walls?" Funded by the Leverhulme Trust from 2014-2018.
  • Shingo Makishi and Chikara Dohno from SANKEN, Osaka University, DNA nanostructures on lipid bilayers.

...

In the past I have collaborated with Prof. Arvind Raman (Purdue), Prof. Hiroshi Iwasaki (Osaka U), Prof. Hiroyuki Noji (Tokyo U), Prof. H. Tabata (Tokyo U), Prof. Sergi Civit (U Barcelona), Dr. Roger Proksch (Asylum Research), Dr Stephan Grage (Karlsruhe), Prof. Ando's AFM lab, ... and a lot of great researchers!

NEWS:


- Paper accepted in the Journal of Materials Chemistry B:
"Sub-nanoscale free volume and local elastic modulus of chitosan/carbon nanotube biomimetic nanocomposite scaffold-materials"
This paper describes new methods to control two key parameters of future materials for drug-delivery and tissue engineering: nanoscale mechanical properties and mass transport (free volume) using atomic force microscopy (AFM) and positron annihilation spectroscopy (PALS).
The authors of this work are: Eneko Axpe, Loic Bugnicourt, David Merida, M. Goiriena-Goikoetxea, Iraultza Unzueta, R. Sanchez-Eugenia, Jose Angel Garcia, Fernando Plazaola and Sonia Contera.

-I am teaching the course "Nanotechnology in Medicine and Biology" at Sichuan University's 2015 Immersion Programme in Chengdu, next July.

-Prof Javier Garcia Martinez director of the Molecular Nanotechnology Lab at the University of Alicante, awarded the prestigious Oxford Martin School Visiting Fellowship for a month visit in May-June 2015, at Contera Lab, Oxford Martin Programme on Nanotechnology.
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Our new book Anticipating 2025: A guide to the radical changes that may lie ahead, whether or not we're ready, is out!

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Head of the Biophysics teaching lab at Oxford Physics from 2014

Coordinator (2013) of the Doctoral Training Center 2 weeks Module on Biological Physics 2013
DTC Modules information here

Teaching AFM and AFM practicals for the DTC Advanced Biophysics Module

Major Option C7: Biological Physics
-Protein structure and folding
-Protein nanomechanics

Physics Today lecture
(1st Year) 2012
http://www.physics.ox.ac.uk/users/westb/PhysicsTodayLectures.pdf
-Physics and the future of biology and medicine

Practical Course: Biophysics BP03*****
-Atomic Force Microscopy
(5 star student rating)
-3rd Year Mini Project: biopolymer physics with atomic force microscopy

Biochemistry Department
Bionanotechnology short-option. Atomic Force Microscopy

PHYSICS AT THE INTERFACE OF NANOTECHNOLOGY, BIOLOGY AND MEDICINE

My research integrates biological physics, nanoscience and scanning probe microsocopy for biomedical applications.

My motivation is to use physics and nanotechnology to understand biological problems and the other way around: to learn from biology to create new bioinspired materials and applications

Physics in biology and how it happens at the biological scales from nm to micron to macroscopic.

  • Interests include: cell mechanical properties, single molecule nanomechanics, membrane protein biophysics, DNA nanomechanics, molecular motors, membrane biophysics.
    Live cell mechanical comminication, shapes, sizes and growth, cells in tissues
    Cell Rheology in 2D/3D culture and in tissues.
  • Molecular forces in biology, physicochemical interactions at bionano-interfaces, nanostructure/biomolecule/cells interactions
  • Interfaces: nanostructured surfaces/liquid-solid interfaces, nano-bio interfaces.

Applications:

  • Biomimetic functional materials
  • (Nano)physics for medicine, (drug-delivery, tissue engineering, biosensing).

Techniques:

  • High-resolution/high-speed/ atomic force microscopy (AFM), scanning probe microscopy in biology, mechanical properties mapping.
  • Force spectroscopy

Some biological problems I am interested in: cell mechanics,cytoskeleton, extracellular matrix, membranes and membrane proteins

Events, outreach, talks, webcasts, press coverage/contributions....

Blog of events:

-Invited in Seville's "Jornadas del futuro cientifico" on Nanotechnology and Physics in Biology, Medicine and Tissue Engineering, on the 27th Feb. More info here.

- Speaker at the SANKEN Core to Core Symposium, 12 December 2015, Osaka, Japan

- I have written Física y nanotecnología en ingeniería de tejidos, o cómo comunicarse con las células usando fuerzas (In Spanish) for Prometeo-us: Blog de Ingeniería Tisular y Medicina Regenerativa.

- Participant at the World Economic Forum Global Agenda Council on Nanotechnology Meeting. Dubai 09-11 November 2014.

- Public lecture at the Cambridge University Physics Society, Wed 26 Nov 2014.

- Invited speaker at Barcelona BioMed Conference on “Transporters and other membrane molecular machines (structures and single molecule analysis)” Barcelona on 17-19 November, 2014.
-Seminar at the Faculty of Science & Technology, University of the Basque Country, Bilbao, Friday 26 Sept 2014.

-Some fotos of the Core to Core Symposium on biosensing that we hosted on the 24-25 July

-Invited speaker, Gordon Research Conference on Membrane Transport Proteins, Keynote Session: New Methods in Membrane Transport Research. July 13-18, 2014 Mount Snow Resort, West Dover, VT USA

- Invited Speaker at Bristol Nanoscience Symposium 2014. Dates: Sunday 14th, Monday 15th and Tuesday 16th September 2014

- Public lecture at the Cambridge University Physics Society, Michaelmas 2014 date and venue TBA

- Invited speaker at Barcelona BioMed Conference on “Transporters and other membrane molecular machines (structures and single molecule analysis)” to be held in Barcelona on 17-19 November, 2014.

-24-25 July at Oxford : Next Generation Sensor Devices for a Healthier, Safer Society - International Networking workshop

-Our new book Anticipating 2025: A guide to the radical changes that may lie ahead, whether or not we're ready, is out!
http://www.amazon.co.uk/gp/product/B00L2EAUP8
http://www.amazon.co.uk/gp/product/B00L2EAUP8

I took part in the Forces in Biology Meeting: 19th/20th March 2014, http://www.physicsoflife.org.uk/events/forces-in-biology/

I was invited speaker at Anticipatintg 2025, Sat 22 and Sun 23 March 2014, Birkbeck College, London. A fantastic event with a great panel of speakers trying to make a serious analysis of the potentially radical scenarios that may unfold between now and 2025.
VIDEO HERE

Webcasts of the event "How can we capture the possibilities but avoid the pitfalls of nanotechnology?" - Next Big Thing Here
My bit is here:

26 March 2013 18:30 - 19:45 Nesta, 1 Plough Place, London, EC4A 1DE
Speaker at the Next Big Thing: This London-based event is a collaboration between the Oxford Martin School, Policy Exchange and Nesta: "How can we capture the possibilities but avoid the pitfalls of nanotechnology?" - Next Big Thing More information here
Speakers:

  • Dr Sonia Contera, Co-Director, Oxford Martin Programme on Nanotechnology
  • Dr Eric Drexler, Oxford Martin Programme on the Impacts of Future Technology
  • Professor Richard Jones, Pro-Vice-Chancellor for Research and Innovation, University of Sheffield
  • John Knowles, Chairman, Advisory Board, UK Nanotechnology Knowledge Transfer Network

Chair: Jessica Bland, Technology Futures, Nesta
Join in on Twitter - #nextbigthing
For more information and booking a seat, please visit www.eventbrite.com/event/5439275018

Interviewed on Nanotechnology for Medicine by Strategic North for the publication STRATEGIC TALES
The interview is here

Feb 2013: GRANT awarded by JSPS for “International Research Collaboration Network for Developing Highly Functional Sensing Devices for Health, Safety and Security", within the frame work of the JSPS Core to Core Program, for a collaboration of Osaka Univeristy's SANKEN institute for collaboration wirh labs from Belgium, Germany, The Netherlands, USA, France and my lab in Oxford. 19,850,000 yen/year x 5 years.

Feb 2013: I am interviewed for the Spanish edition of Glamour Magazine!
glamour spglamour sp

15 Feb 2013 Manga author Riko Miyagi visits our lab to research for a new Manga series on a Woman Scientist...

17 Jan 2013 PUBLIC LECTURE 'Nanotechnology and the future of medicine'British Science Association Oxford Branch SciBar PODCAST AVAILABLE

26 DEC 2012, 1 page feature in the print edition of the most popular Spanish Newspaper El Pais, featuturing our work on the future of medicine and an interview. The online edition is here link

Dec 2012. JAPAN TRIP funded by the EPSRC programme Bridging the Gaps 2012. I am visiting Noji's lab at Tokyo University and giving two lectures to master students at the Dept of Chemistry of Tokyo University on AFM and protein nanomechanics. I am also participating in a Symposium at SANKEN , Osaka University as invited speaker and then visiting Tabata lab at Tokyo University for discussing collaboration in IR, THz spectroscopy and nanomaterials...

3 Dec 2012 PUBLIC LECTURE. Physics and the future of medicine.
6:00pm - 7:00pm Martin Wood Complex, Department of Physics, University of Oxford, Parks Road, Oxford, OX13PU, General public (Age 14+)

SIX FUTURE FORMS
SIX FUTURE FORMSSIX FUTURE FORMS
Nanotechnology feature for the WIRED MAGAZINE special issue on the WIRED WORLD 2013.
You can read the piece here
The piece has also be featured in WIRED MAGAZINE ITALIAN EDITION

Wired 2011: How physicists are moving into biology
WATCH VIDEO HERE

THE FUTURE OF MEDICINE
WATCH VIDEO HERE

PANEL DISCUSSION AT THE OXFORD MARTIN SCHOOL
Emerging healthcare technologies - how are they changing us?

Feature on my work in Spanish National Newspaper EL Mundo on Tissue Engineering
here