Stephan Uphoff

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Stephan Uphoff

Group leader Department of Biochemistry

My lab is in the Department of Biochemistry at Oxford. We investigate DNA repair and mutagenesis, seeking to understand the mechanisms of DNA repair pathways and how mutation rates are regulated through DNA damage responses. Our goal is to directly measure these fundamental processes inside individual living cells. To this end, we develop single-molecule/super-resolution microscopy, single-cell manipulation, microfluidics, flow cytometry, and whole genome sequencing techniques. We also advance data analysis and computational modeling for quantitative descriptions of DNA repair and mutagenesis. We are currently very interested in the consequences of gene expression noise and stochastic processes on the fidelity of genome maintenance. Our work with bacterial cells also informs about the origins of mutations that lead to antibiotic resistance.

I obtained my DPhil under the supervision of Achillefs Kapanidis at Oxford Physics and worked as a postdoc with Johan Paulsson in the Systems Biology Department of Harvard Medical School and with David Sherratt’s group in the Biochemistry Department at Oxford. Research in my group is funded by the Wellcome Trust and a Junior Research Fellowship at St John's College.

For more information, please visit my research website by following the link below.