Sonia Trigueros

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Sonia Trigueros

Co-Director OMS Intitute of Nanoscience for Medicine

NanoBioSystems Group
Academic Fellow at Oxford Physics Department.
Co-Director of the Oxford Martin Programe on Nanotechnology (Institute of Nanoscience for Medicice)
Expertise in Molecular Cell Biology, Biochemistry, DNA Topology, Nanoscience and Nanobiology.

@TriguerosS

My current research is focus on the design of novel nanostructures to target DNA Biomolecular Motors (DNA topoisomerases and DNA translocases) and particular DNA conformational states in dividing cells.

Through the activity of DNA topoisomerases, cells modulate the degree of supercoiling, knotting and catenation of DNA strands. Biochemical and genetic manipulation of these enzymes allow altering the intracellular DNA topology and studying its effect on chromosome activities and DNA organization. Eukaryotic DNA topoisomerases are the targets of a broad spectrum of chemiotherapy drugs. Prokaryotic DNA topoisomerases are the targets of several antibiotics.

Summary of my Current Research Projects in Nanomedicine

Project 1 Basic Research on DNA molecular motors-drug interaction: Basic Research on DNA Atomic Structures/DNA molecular motors: Intracellular targets for novel nanomedicines

Project 2 Development: Smart NanoSystems: Nanotechnology for design Drug Delivery System that is Soluble, Stable, Reversible, and Universal

Project 3 Monitoring cell-nanoparticles effects: Mapping morphological and nanomechanical properties of live cells in near-physiological conditions using multi-harmonic tapping-mode atomic force microscopy

Project 4 Monitoring Toxicity: Mechanisms of cell-nano-particle interaction

Project 5 Nano-Gene-Delivery System: Nanotechnology on Genome editing. The Future of genetic blindness. New project funded by OMS from April2016.

Project 6 Development of a novel method for generation of attenuated bacteria vaccines by in vivo DNA condensation

  • Oxford Lecture Nanotechnology for Medicine. Graduated Course Departemnt of Physics. Oxford University 2013-2016
  • •Tutor lead in Oxford Summer School/Master in Nanomedicine.July 2013. University of Oxford. Department for Continuing Education Begbroke Science Park.
  • •Tutor lead in Oxford Summer School/Master in Nanomedicine. 4-8 July 2011. University of Oxford. Department for Continuing Education Begbroke Science Park.
  • •PhD in Physics. Supervisor (2009-12)Student: Amadeus Stevenson. University of Oxford.
  • •Master in Biotechnology. Supervisor (2011). Student Adria Sales. University of Barcelona.
  • •I delivered Course on “Advance Course of Nanotechnology for Medicine” Medicine Department. University of Havana. Cuba 01-05/10/2010.
  • •I delivered Course on “Advance Course of Nanotechnology for Medicine” at CNIC / Havana Cuba 23-28/06/2010.
  • •I delivered Course on Nanotechnology for Medicine at CNIC / University of Medicine. Havana Cuba 20-27/May/2009.
  • •MS in Physics. Supervisor Oxford Physics (2009-10).
  • •Supervisor in Final degree research project Oxford Physics (2008-2010)
  • •Teaching Assistant in Physics. Third year Biophysics. Oxford University (2008-2010).
  • •Tutor in DNA topology. Second year Biochemistry. Oxford University (2006-2010)
  • •Tutor in DNA recombination, replication and DNA repair. Second Year Biochemistry. Oxford University. (2006-09)
  • •Teaching Assistant in Biochemistry. First year Biochemistry. Oxford University (2007).
  • •Supervisor in Final degree research project Oxford Biochemistry students (2005-07)
  • •Mentor in Research Training Program (MHIRT) 5T37MD001368-09. College of Natural Science and Mathematics. 800 N State College Boulevard, Fullerton, CA (June-September 2004-2007).
  • •Teaching Assistance in Molecular genetics. Second Year Biochemistry. Oxford University (2006).
  • •Teaching Assistance in Molecular genetics. Second Year Biochemistry. Harvard University (2003).
  • •Tutor in Molecular Biology Master in Science Program. University of Massachusetts. Boston. (2002).
  • •Instructor for Methods in Molecular Biology. Narcis Monturiol Technician College. Barcelona Spain. (1997-2000).

'Nanotechnology: the big picture' with Dr Eric Drexler and Dr Sonia Trigueros
Advancements in nanotechnology could fundamentally change global approaches to manufacturing, medicine, healthcare, and the environment. In this lecture Dr Eric Drexler, Senior Visiting Fellow, Oxford Martin School, will look at current advances in the field of advanced nanotechnology, and the impacts and potential applications of their widespread implementation, and Dr Sonia Trigueros, Co-Director of the Oxford Martin Programme on Nanotechnology, and Oxford Martin Senior Fellow, will consider how targeted nanomedicine could change how we treat disease in the future.


TEDx
Sonia Trigueros designs novel nanostructures capable of delivering drugs directly to a targeted area of the human body. This revolutionary technology may be able to treat everything from antibiotic resistant bacteria to cancer.