Publications by Jonathan Bath


Sequence-specific synthesis of macromolecules using DNA-templated chemistry.

Chem Commun (Camb) 48 (2012) 5614-5616

PJ Milnes, ML McKee, J Bath, L Song, E Stulz, AJ Turberfield, RK O'Reilly

Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.


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